5-HTP Supreme™ is a synergistic formula of 5-hydroxytryptophan (100 mg) and vitamin B6 (20 mg) per serving for supporting overall neurotransmitter metabolism by providing precursors of serotonin. 5-HTP readily enters the blood–brain barrier; however, conversion into serotonin requires the cofactor vitamin B6, which is included in this formula. 5-HTP Supreme™ may be used during the day to support a healthy mood and normal appetite, or it may be used at bedtime to support sleep.* This formula can be used in place of 5-HTP Synergy™ when higher doses of 5-HTP are recommended.