Description for Vitamin B2

Echinacea may inhibit the human drug metabolizing enzyme CYP1A2 leading to decreased clearance (increased blood levels) of Zyprexa®, and this increases potential for side effects.

Seizures have been reported in people with schizophrenia treated concomitantly with phenothiazine drugs and evening primrose oil.

Ginkgo has been report to cause seizures or lower seizure threshold. Thus, in combination with drugs that lower seizure threshold (including antipsychotics), there may be a significant increase in risk of seizures.

Ginseng may exacerbate some psychiatric conditions including hysteria, mania, and schizophrenia and thus compromise the therapeutic benefit of antipsychotics. It may also inhibit some of the drug metabolizing enzymes responsible for clearance of antipsychotic drugs.

Goldenseal can inhibit cytochrome P450 2D6 (CYP2D6) and might affect effectiveness of several antipsychotics as well as impact potential for side effects.

St. John's wort in combination with antipsychotic drugs may lead to unpredictable effects. It is also known to cause photosensitivity and this risk may be increased in combination with certain antipsychotics (phenothiazines), which also can cause photosensitivity.